Agenda

Opening remarks

[ T Angata ]

Plenary lectures

[ Chair: Jim Paulson ]

Matthew Macauley

Development of biochemical tools to interrogate the role of immunomodulatory Siglecs

Peng Wu

Degrading Inhibitory Siglecs for cancer immunotherapy

Reception (Room 208-209, IBC)

[ All participants ]

Session 1 : Sialic acid in infection and immunity

[ Chair: Kuo-I Lin ]

Amanda Lewis

Bacterial enzyme-driven glycan remodeling in bacterial vaginosis

Shie-Liang Hsieh

CD33 blockade restores coordinated antiviral immunity and accelerates HBsAg clearance in chronic hepatitis B

Takeshi Tsubata

CD22 (Siglec-2) is a therapeutic target for autoimmune diseases and graft rejection through expansion of regulatory B cells 

Ho-Yang Tsai

The α2,8-disialyl motif modulates B-cell receptor signaling

Break 休息

Session 2 : Sialic acid and viral infection

[ Chair: Mark von Itzstein ]

Robert de Vries

The receptor binding landscape of contemporary H5Nx viruses

Arun Everest-Dass

Desialylation and glycan class-specific remodelling define the host glycome response to HPIV-3 infection

Ruonan Liang

The loss of turkey erythrocyte binding of human influenza A(H3N2) virus, subclade K, explained at the molecular level

Shinobu Kitazume

Endothelial APP O-GalNAc glycosylation via retrograde trafficking in cerebral amyloid angiopathy

Lunch 午餐

Session 3: Sialyltransferases: Properties and utilities

[ Chair: Ching-Ching Yu ]

Chun-Cheng Lin

Enzymatic synthesis of sialosides, with emphasis on gangliosides

Somanath Kallolimath

Production of polysialic acid in a sustainable plant expression system using salmonid polysialyltransferases

Yu-Tong Lin

Site-selective control of sialylation by chemoenzymatic method and protecting group modulation strategy

Sushmaa Dangudubiyyam

Accelerating the discovery of sialyltransferase inhibitors with speed, efficiency, and specificity

Break 休息

Session 4: New technologies

[ Chair: Takashi Angata ]

Kiyoko Aoki-Kinoshita

AI-ready data for glycoscience

Chi-Kung Ni

Differentiation of α2-3- and α2-6-linked sialic acid linkages using esterification/amidation reactions and tandem MS

Chien-Hui Lo

Streamlining the use of human lectins for immunological assays and immunostaining

Lori Yang

SiaFind™ and N-GlyFind™: Engineered affinity reagents for the detection and enrichment of sialylated N-glycoconjugates

Xinghai Ning

Programmable glycochemistry for functional glycan engineering

Jon Lundstrøm

Enzyme-linked cycloaddition assay (ELCA) for rapid, ultra-sensitive monitoring of secreted sialoglycoproteins

Session 5: Natural and unnatural sialic acids

[Chair: Andrew Bennet]

Xi Chen

Sialosides containing modified sialic acid as sialidase substrates and inhibitors

Ken Kitajima

Unique properties and biological significance of deaminoneuraminic acid (Kdn) at the 40th anniversary of its discovery

Sean Burnap

Design of a photoreactive chemical cross-linker for metabolically engineered glycoproteins

Sota Yamashita

Detection of unique modified sialic acids in echinoderms using a fluorescent labeling/LC-MS method

Break 休息

Session 6: Siglec-ligand interaction

[ Chair: Matthew Macauley ]

June Ereño Orbea

Targeting Siglec–sialoglycan interactions: structural insights and therapeutic opportunities

Rafael Martinez-Carrasco 

The human corneal epithelium presents Siglec‑7 ligands that are diminished in inflammatory conditions

Thomas Haselhorst

Towards second-generation high-affinity Siglec-2 ligands

Lorena Perez-Gutierrez

Sialic acid–dependent inhibition of T cells via Siglec-9 limits anti-tumor immunity 

Lunch 午餐

Poster session 

Odd number

Even number

Session 7: Sialic acid and cancer

[ Chair: Herbert Hildebrandt ]

Michael Jennings

N-glycolylneuraminic acid as a carbohydrate cancer biomarker

Tan-chi Fan

Sorafenib resistance-induced hypersialylation promotes tumor immune evasion

Chuan-Fa Chang

Loss of ST8SIA6 promotes colorectal cancer metastasis by enhancing MUC16-integrin β4 signaling

Kenward Vong

Targeting hypersialylation in metastatic cancer cells using lectin-directed protein aggregation therapy (LPAT) 

Ziqian Peng

Targeting Siglec-engaging immunosuppressive sialoglycans to suppress prostate cancer bone metastasis

Xavier de Bisscop

Investigation of serum N-glycolylneuraminic acid glycoconjugates in pancreatic cancer

Banquet

(Invitees and paid participants only)

Session 8: Sialic acid and neuroscience-1 

[ Chair: Elena Chiricozzi ]

Yijuang Chern

A CD22-dependent glyco-immune checkpoint drives impaired microglial phagocytosis in Huntington’s disease

Herbert Hildebrandt

Polysialic acid deficiency leads to microglial priming in the adult mouse cortex

Chihiro Sato

Discovery of a new polysialic acid-synthesizing enzyme in brain

Name

Break 休息

Session 9: Sialic acid and neuroscience-2 

[ Chair: Yann Guerardel ]

Elena Chiricozzi

The GM1 pentasaccharide: emerging concepts in neurodegeneration

Ana Cindric

Trisomy 21 reshapes the neural N-glycome during early differentiation

Thomas Klarić

Evolution and development of the human brain through the lens of protein N-glycosylation

Kim Wai Parn

Identification of a mammalian sulfotransferase that transfers a sulfate group onto core fucose on N-glycans

Lunch 午餐

TGA session 1 

[ Chair: Todd Lowary ]

Pei-Jhen Li

TGA Early Career Award lecture

Chian-Hui Lai

Multifunctional glycofullerene–β-cyclodextrin supramolecular platform for electrochemical sensing and chemo-photodynamic therapy

Yves Hsieh

Glycocode: Structural diversity of polysaccharides and the enzymatic machinery that shape them

Ching-Ching Yu

Decoding of carbohydrates with monosaccharide-level resolution using tip-enhanced Raman scattering

Sefunmi Akinseye

Correlating reactivity and stereoselectivity of disaccharide donors in glycosylation reactions

M Tarique Anwar

Chemoenzymatic synthesis of defined O-antigens reveals mechanistic insights into biosynthesis

Break 休息

TGA session 2

[ Chair: Kay-Hooi Khoo ]

Hung-Lin Chen

Galectin-4 modulates tumor microenvironment and glycosylation in colorectal cancer: Insights from multi-omics analysis

Yung-Chi Chang

Siglec-14 drives tumor-associated macrophage polarization and immune suppression in colorectal cancer through recognition of tumor-derived sialylated ligands

Yen-Ying Chen

Making tumor glycans druggable: A protease-activated antibody strategy for safer cancer targeting

Neng-Yu Lin

TBA

Ren Hao Yeh

Tracking of heparan sulfate species with scFvs

Closing remarks

[ By: Kay-Hooi Khoo ]